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According to studies, PKC stimulation increases the expression of StAR and leads to production of progesterone in granulosa cells [62, 63]

Tumor Microenviron Ther

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doi: 10.3389/fimmu.2025.1699210 Received 05 September 2025 Revised 05 November 2025 Accepted 07 November 2025 Published 03 December 2025 Volume 16 - 2025 Edited by Stefan Tukaj, University of Gdansk, Poland Reviewed by Immadi Sudhakar Vamshidhar, All India Institute of Medical Sciences, India Alireza Arefzadeh, Islamic Azad University Central Tehran Branch, Iran Updates Copyright 2025 Murugan and Alzahrani

132 WangM.MaoC.OuyangL.LiuY.LaiW.LiuN.et al (2019)

Another trial in 54 individuals confirmed its safety over 10 days of intravenous use at doses of up to 5.0g/kg (and up to 25.0g/kg in a single-dose trial)